Tricyclic antidepressants are associated with many side effects, which is one of the reasons doctors prescribe newer antidepressants that tend to have fewer side effects. Not all patients will be able to tolerate these side effects, especially at higher doses, but in many (though not all) cases, side effects will subside within three to four weeks as the body adjusts to the medication.
Common side effects can include feeling tired or sedated, “spacey,” “slowed down” or forgetful. Tricyclic antidepressants also lead to what are known as anticholinergic side effects, including dry skin and mouth, blurred vision, constipation and difficulties urinating. Other side effects include dizziness, weight gain and sexual problems.