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Tricyclic Antidepressants (TCAs)

Conditions Related to Tricyclic Antidepressants (TCAs)

Tricyclic antidepressants are first-generation antidepressants; discovered in the 1950s, they were among the first chemical compounds used to treat symptoms of depression. Today, while they are still prescribed for some cases of depression, many physicians use second- and third-generation antidepressants such as bupropion and fluoxetine for depression, as they tend to be just as effective as tricyclic antidepressants but have fewer side effects.

Tricyclic antidepressants are frequently taken for “off-label” conditions, including insomnia, chronic pain syndromes, generalized anxiety disorder, obsessive-compulsive disorder, mood disorders, pain disorder, eating disorders (e.g., bulimia nervosa), migraines and premenstrual dysphoric disorder (PMDD). 

Locations for Tricyclic Antidepressants (TCAs)