Ongoing research into restless leg syndrome (RLS) is increasing understanding of the physiological mechanisms of the disorder, improving diagnostic procedures and treatments and moving closer to identifying the specific causes, finding a cure and prevention.
A significant amount of research of RLS focuses on the relationship of the disorder to dopamine, a chemical that transmits nerve impulses to muscles. The medical evidence indicates that involuntary movements may relate to a dysfunction in the nerve pathways that use dopamine. Other studies seek to learn about the complex relationship of dopamine and iron deficiency, which can produce severe RLS symptoms in older adults. A number of clinical trials for restless leg syndrome investigate the potential of drug therapies in relieving symptoms and reversing causes.