Each year, some 150,000 new cases of colorectal cancer are diagnosed in the U.S. Over 40,000 of those cases are diagnosed with rectal cancer. Men are at a slightly higher risk for colorectal cancer than women. At the highest risk for the disease are African-American men. People of Ashkenazi Jewish ancestry have a higher probability for l1407K, a genetic mutation that increases the risk for colorectal cancer. People living in the U.S., Japan and other developed countries are at a higher risk than those living in developing countries.