The serious nature some related conditions of hydatidiform mole require additional medical attention and, at the least, warrant regular follow-up after treatment.
Rarely hydatidiform moles develop into invasive moles that implant deeply into the uterine wall. These tumors remain in the uterus even after a suction curettage (a D and C). A standard treatment in molar pregnancy, it is possible for the D and C procedure to damage the uterus or fallopian tubes, possibly leading to an ectopic pregnancy or other complications. . Preeclampsia and thyroid problems are also possible problems caused by surgery for hydatidiform mole.
The most serious related condition of hydatidiform mole is that it can develop into a chroriocarcinoma, a malignant tumor. Choriocarcinoma grows quickly and spreads rapidly, sometimes moving to the liver and brain. Chemotherapy is used successfully to treat this cancer, but has several side effects such as nausea, reduced appetite, low energy and hair loss. In some very rare cases, the chemotherapy drugs used have led to leukemia.